Collagen & Gelatin
About Collagen, gelatin, and collagen peptide
Valuable properties of collagen and gelatin for medical applications
Functions of collagen
Most cells express collagen binding proteins (e.g. Integrin) on their surface; therefore, collagen shows impressive cell attachment.
Some types of cells can efficiently grow and differentiate by recognizing collagen molecules. Taking advantage of this property, collagen is being used as a superior raw material in medical devices including artificial skin and bone grafts. In addition, it has recently been used as a culture substrate for tissue formation from stem cells.
Collagen solutions can readily form gels by adjusting the salt concentration to physiological conditions and incubating at 37°C. Therefore, it is possible to culture cells in or on collagen gel. Collagen gel has been used as a research tool for a long time. In addition, it has recently been applied to medical uses such as transplantation and as a carrier for cell therapy.
Function of gelatin
It is known that the cell adhesiveness of gelatin is not strong. However, gelatin can strongly bond with fibronectin, which is a cell adhesion molecule existing in blood or in culture medium. Therefore, it is possible to achieve high cell adhesion in culture devices by gelatin coating.
Gelatin solution has sol-gel transition type-temperature responsivity. Thus, it can form a gel on cooling and can be liquefied upon heating. This reversible reaction is the most unique function of gelatin and is used for various applications.
Chemical modification property
Gelatin can readily dissolve in water and some kinds of organic solvents. In addition, it has several amino and carboxyl groups and can therefore be easily modified with various chemical reagents.
Some types of gelatin show high viscosity. Therefore, it is possible to alter the viscosity of medical drugs to achieve optimal effects by adding gelatin.
Protective colloid property
Gelatin is a hydrophilic colloid displaying a protective colloidal property. It can be thus used to inhibit the flocculation of hydrophobic colloids.
Formability of collagen and gelatin
The above products are sold for research purpose only. Regardless of purposes, such as production of drugs, product quality control, various diagnostic test, medical treatment, or other researches, do not use products for human body.